The ¹⁰³Pd/^103mRh in vivo generator is a promising Auger electron emitting system. This study investigates daughter radionuclide release and mechanisms governing bond rupture and retention. ¹⁰³Pd was produced via cyclotron irradiation, separated, and used to radiolabel DOTA-TATE, phthalocyanine-TATE, and DOTA-TOC. Complexes were immobilized on Strata-X and Strata-C18 columns, and elution experiments quantified ^103mRh release. Release rates ranged from 9.6% to 12.0%, significantly lower than the ~100% predicted from Auger yield. Delocalized π-electrons did not reduce release. Low daughter release supports clinical potential, indicating Auger cascades dominate bond rupture over nuclear recoil.

• This seminar introduces the article of the month 2026/3 at Atomki:
  Evaluation of daughter radionuclide release from the 103Pd/103mRh in vivo generator for targeted Auger therapy,
  Pharmaceuticals 19 : 1 Paper: 126 , 16 p. (2026).
   

• Tea and cookies are offered 30 minutes before the seminar.